@article{JLPM4258,
author = {Merve Sibel Gungoren and Cumali Efe and Taylan Kav and Filiz Akbiyik},
title = {Diagnostic accuracy of enhanced liver fibrosis (ELF) test for significant fibrosis in patients with autoimmune hepatitis},
journal = {Journal of Laboratory and Precision Medicine},
volume = {3},
number = {3},
year = {2018},
keywords = {},
abstract = {Background: Although, liver biopsy is currently the gold standard tool for monitoring fibrosis progression, it is an invasive method and associate with some minor and major complications. Several non-invasive markers have been developed for assessment of liver fibrosis, but their validity has not been well studied in autoimmune hepatitis (AIH). The enhanced liver fibrosis (ELF) test is an alternative, non-invasive method for monitoring fibrosis progression. In this study, we evaluated performance of ELF test for predicting fibrosis stage in patients with AIH.
Methods: Serum samples of 46 consecutive patients who were diagnosed with AIH were analyzed, and calculated for ELF scores. All patients underwent a liver biopsy. Patients with ≥F2 were considered to have a significant fibrosis according to the METAVIR scoring system. Diagnostic accuracy of ELF was evaluated with the receiver operator characteristic (ROC) curves analysis.
Results: The mean ELF scores were significantly higher in patients with significant fibrosis that those with mild fibrosis (10.60±1.39 vs. 8.62±1.05, P},
issn = {2519-9005}, url = {https://jlpm.amegroups.org/article/view/4258}
}