@article{JLPM4259,
author = {Vincenzo Roccaforte and Massimo Daves and Vanessa Proserpio and Flavia Sciarini and Rosella Sangiorgio and Arcangelo Costanzo and Angela M. Di Pierro and Salvadori Ugo and Giuseppe Lippi and Claudio Bonato},
title = {Evaluation of body fluid mode of Sysmex XN-9000 for white blood cell counts in cerebrospinal fluid},
journal = {Journal of Laboratory and Precision Medicine},
volume = {3},
number = {3},
year = {2018},
keywords = {},
abstract = {Background: This study was planned to evaluate the analytical performance of the novel and fully automated Sysmex XN-9000 analyzer for rapid analysis of cerebrospinal fluid (CSF) samples.
Methods: Forty-four CSF samples were used for method comparison studies between Sysmex XN-9000 body fluid mode and conventional optical microscopy. The bias between data obtained with the two methods was estimated with Bland-Altman plot analysis. The analytical evaluation also included the assessment of imprecision, linearity and carry-over.
Results: A good agreement was found between results obtained with Sysmex XN-9000 body fluid mode and optical microscopy. The mean bias was 1.6×106 cells/L for total white blood cells (95% CI: −21.8×106 to 25.1×106 cells/L), 1.3×106 cells/L for polymorphonuclear cells (95% CI: −13.9×106 to 16.5×106 cells/L) and −0.6×106 cells/L for mononuclear cells (95% CI: −21.5×106 to 20.3×106 cells/L). The carryover was found to be lower than 0.01% and the imprecision was lower than 5%. The XN-9000 body fluid mode was also characterized by excellent linearity in the range of values comprised between 85×106–3,197×106 cells/L, with correlation coefficients (r) always equal to 1.00 (P},
issn = {2519-9005}, url = {https://jlpm.amegroups.org/article/view/4259}
}