Is Keratin-18 only a marker of cell death in acute-on-chronic liver failure?

Acute liver failure (ALF) due to a variety of causes has been well established clinically for a number of decades (1). An intense research focus has recently been generated in the realm of acute-on-chronic liver failure (ACLF), especially in light of the high number of cirrhotic patients that eventually present to the clinic (2). The pathology and clinical history of ACLF is poorly understood and due to its nebulous clinical nature, there are no current mainline treatments.