Editorial on “Cerebrospinal fluid total protein reference intervals derived from 20 years of patient data”

Analysis of cerebrospinal fluid (CSF) proteins continues being a basic tool for diagnosis and follow up of many neurological diseases, even when at present some consider that advanced imaging techniques have displaced CSF studies. In certain clinical settings, CSF-total proteins (TP) is sometimes the closest approximation to the central nervous system (CNS), and diagnostic or referral decisions with only CSF TP might be necessary.